DRUG NAME : ERYTHROMYCIN BACTERIAL RESISTANCE CLASS OF DRUG :MACROLIDES. FOUNDED YEAR : 1952 ISOLATED FROM: STREPTOMYCES ERYTHREUS. MECHANISM OF ACTION : BLOCKS 50S RIBOSOMES -INHIBITS THE PROTEIN SYNTHESIS - BACTERICIDAL ACTIVITY. Macrolide antibiotics are bacteriostatic agents that inhibit protein synthesis by binding reversibly to the 50S ribosomal subunits of sensitive organisms. Erythromycin appears to inhibit the translocation step such that the nascent peptide chain temporarily residing at the A site fails to move to the P, or donor, site. Alternatively, macrolides may bind and cause a conformational change that terminates protein synthesis by indirectly interfering with transpeptidation and translocation ANTIMICROBIAL SPECTRUM: streptococcus pyogenes streptococcus pneumoniae niseria gonorrhoeae clodtridia clostridium diphtheria clostridium listera campylobacter legionella branhamella catarrhalis gardnerella vaginallis mycoplasma Helico...
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